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. Author manuscript; available in PMC: 2015 Jul 24.
Published in final edited form as: Nature. 2014 Jun 22;511(7510):428–434. doi: 10.1038/nature13379

Figure 1. Recurrent SVs activate the GFI1B proto-oncogene in MB.

Figure 1

(a) Genome-wide SVs identified by WGS in a discovery cohort of Group 3 and Group 4 MBs (n=137). (b) Summary of SVs affecting a common locus of aberration on 9q34. (c) Expression boxplots (n=96) for the 7 genes contained within the 9q34 region of interest. (d) GFI1B expression across MB subgroups (n=727). Dashed line delineates the threshold for detectable expression (see Online Methods). (e) GFI1B expression for Group 3 and Group 4 MBs (n=119) coloured according to 9q34 SV state. Dashed line indicates the threshold for detectable expression (see Online Methods).