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. Author manuscript; available in PMC: 2015 Jul 24.
Published in final edited form as: Nature. 2014 Jun 22;511(7510):428–434. doi: 10.1038/nature13379

Extended Data Figure 1. Recurrent somatic copy-number aberrations target a common region on 9q34.

Extended Data Figure 1

Affymetrix SNP6 copy-number output for 22 primary MBs from the published8 MAGIC series exhibiting focal somatic copy-number aberrations within the 9q34 region of interest defined by WGS in the current study. Of the affected samples, MB subgroup information was available for 15/22 cases: SHH (n=1*), Group 3 (n=11), and Group 4 (n=3). Close examination of the single non-Group 3/Group 4 MB affected by a focal copy-number event in the region (MB-1318, SHH), revealed that this sample exhibits a homozygous deletion (in the context of broad chr9q deletion) specifically overlapping TSC1 and is therefore unlikely to be related to the events which target GFI1B for transcriptional activation. Indicated coordinates are based on the hg18 reference genome (NCBI Build 36.1) that was used in the original MAGIC study.