Table 2. Antimicrobial resistance-associated genes and target genes in A. oleivorans DR1.

Locus_tag DR1	Product	Description	Genes	Fold-change
				Amp	Km	Tc	Nor
β-Lactamases
AOLE_05220	β-Lactamase	Class C β-lactamase	ampC	1.05	−2.06	−3.45	−1.31
AOLE_06930	β-Lactamase class C	Class C β-lactamase	ampC	5.20	1.93	1.03	1.00
AOLE_12585	β-Lactamase	Class C β-lactamase	ampC	1.41	1.19	1.72	−1.09
AOLE_17635	β-Lactamase class C	Class C β-lactamase	ampC	4.20	3.44	1.53	1.25
AOLE_11070	β-Lactamase class D	Class D β-lactamase	blaoxa-66	1.28	−2.14	−1.43	−1.65
AOLE_00775	Metallo-β-lactamase superfamily protein	Metallo-β-lactamase superfamily	fpaA	−2.31	2.51	1.51	−2.19
AOLE_03925	Putative metallo-β-lactamase	Metallo-β-lactamase superfamily	gloB	3.17	2.56	−2.55	−1.06
AOLE_10040	β-Lactamase	Metallo-β-lactamase superfamily	gloB	−1.32	1.72	−3.28	−1.11
AOLE_17515	Metallo-β-lactamase superfamily protein	Metallo-β-lactamase superfamily	gloB	−1.17	−1.05	−1.33	−1.05
AOLE_01440	Penicillin binding protein transpeptidase domain protein		ftsI	−1.03	−1.20	−1.62	−1.03
AOLE_01470	Putative penicillin-binding protein (PonA)		mrcA	−2.22	−4.35	−3.34	−1.11
AOLE_05610	Penicillin-binding protein 1B		mrcB	−1.80	−3.78	−3.30	−1.04
AOLE_14240	Penicillin-binding protein 2		ftsI	−4.09	−1.47	−1.68	−1.16
Aminoglycosides
AOLE_08490	Predicted aminoglycoside phosphotransferase	aminoglycoside 6′-acetyltransferase	aacA4	3.93	1.30	−1.65	−1.07
AOLE_18475	Aminoglycoside2'-N-acetyltransferase(AAC(2′)-Ib)	aminoglycoside 2′-acetyltransferase	aacB	−8.13	2.15	1.99	−1.03
Fluoroquinolones
AOLE_00020	DNA gyrase subunit B	GyrB mutation	gyrB	−1.82	−1.65	−1.48	1.24
AOLE_00595	DNA topoisomerase IV subunit B	GyrB mutation	gyrB	−1.18	1.61	−1.62	2.80
AOLE_04195	DNA gyrase subunit A	His-78→Asn	gyrA	−2.17	−1.51	−3.26	−1.01
AOLE_18380	DNA topoisomerase IV subunit A	GyrA mutation	gyrA	−1.22	−1.56	−2.00	2.92
Efflux pumps
AOLE_00955	MFS transporter, metabolite:H+ symporter (MHS) family protein	MFS-family efflux pump	uhpC	−3.37	1.97	1.31	1.00
AOLE_00175	MFS-family transporter	MFS-family efflux pump	araJ	−1.63	4.02	2.99	1.38
AOLE_01040	MFS-family transporter	MFS-family efflux pump	araJ	−4.27	−3.45	1.14	−1.32
AOLE_12350	MFS-family transporter	MFS-family efflux pump	araJ	−4.03	−2.09	1.02	1.13
AOLE_00050	RND-type efflux pump	RND-family efflux pump	dctP	9.53	−1.03	1.52	1.02
AOLE_04230	Putative RND-family drug transporter	RND-family efflux pump	emrA	2.16	−15.53	−2.57	−1.21
AOLE_09410	RND-type efflux pump	RND-family efflux pump		6.59	1.19	3.25	1.58
AOLE_18750	RND-superfamily exporter	RND-family efflux pump		77.60	19.11	1.34	−1.13
AOLE_00035	ABC transporter ATP-binding protein	ABC-family efflux pump	uup	−3.32	−1.18	−2.10	1.22
AOLE_01345	Putative ABC transporter ATP-binding protein	ABC-family efflux pump	uup	−3.46	1.23	−3.34	1.06
AOLE_17260	ABC transporter ATP-binding protein	ABC-family efflux pump	uup	−3.46	−2.54	−3.51	−1.01
AOLE_00290	Multidrug-resistance protein norM	MATE-family efflux pump	norM	−3.58	−1.34	1.92	−1.03
AOLE_00530	Na+-driven multidrug efflux pump	MATE-family efflux pump	norM	2.40	1.14	1.73	1.16
AOLE_05880	MATE efflux family protein	MATE-family efflux pump	norM	-2.29	−1.69	2.25	1.28
AOLE_17460	Multidrug ABC transporter	MATE-family efflux pump	norM	−3.07	1.57	−1.22	−1.20
AOLE_05535	Quaternary ammonium compound-resistance protein QacE	SMR-family efflux pump	qacE	−2.23	2.48	1.71	1.47
AOLE_16200	Quaternary ammonium compound-resistance protein SugE	SMR-family efflux pump	sugE	−1.59	4.62	1.97	1.15