| Cellular responses |
|
| Autophagy |
ATG16L1, IRGM, NOD2, LRRK2, CUL2, PARK7, DAP |
| Apoptosis/necroptosis |
FASLG, THADA, DAP, PUS10, MST1 |
| ER stress |
CPEB4, ORMDL3, SERINC3, XBP1 |
| Carbohydrate metabolism |
GCKR, SLC2A4RG |
| Oxidative stress |
PRDX5, BACH2, ADO, GPX4, GPX1, SLC22A4, LRRK2, NOD2, CARD9, HSPA6, DLD, PARK7, UTS2, PEX13 |
| Intracellular logistics |
VAMP3, KIF21B, TTLL8, FGFR1OP, CEP72, TPPP |
| Inflammatory response |
PTPN2, PTPN22 |
| Cell migration |
ARPC2, LSP1, AAMP |
| Viral response |
IFIH1 |
| IBD-related processes |
|
| Epithelial barrier |
GNA12, HNF4A, CDH1, ERRFI1, MUC19, ITLN1 |
| Restitution |
REL, PTGER4, NKX2-3, STAT3, ERRFI1, HNF4A, PLA2G2A/E |
| Solute transport |
SLC9A4, SLC22A5, SLC22A4, AQP12A/B, SLC9A3, SLC26A3 |
| Paneth cells |
ITLN1, NOD2, ATG16L1, XBP1 |
| Innate mucosal defense |
NOD2, ITLN1, CARD9, REL, SLC11A1, FCGR2A/B |
| NF-κB |
REL, TNFAIP3, NFKB1
|
| Ubiquitylation |
UBE2L3 |
| Immune cell recruitment |
CCL11/CCL2/CCL7/CCL8, CCR6, IL8RA/IL8RB, MST1 |
| Antigen presentation |
ERAP2, LNPEP, DENND1B |
| IL-23/TH17 |
IL23R, IL12B, JAK2, TYK2, STAT3, STAT4, ICOSLG, IL21, TNFSF15, IL27 |
| T-cell regulation |
NDFIP1, TNFSF8, TAGAP, IL2, IL2RA, TNFRSF9, PIM3, IL7R, IL12B, IL23R, PRDM1, ICOSLG, TNFSF8, IFNG, IL21 |
| B-cell regulation |
IL5, IKZF1, BACH2, IL7R, IRF5, IRF8 |
| Immune tolerance |
IL10, IL27, SBNO2, CREM, IL1R1/IL1R2, NOD2 |
| Other |
ZMIZ1, YDJC, TAGAP, IL18RAP |
