Skip to main content
. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Nature. 2014 Aug 10;514(7522):372–375. doi: 10.1038/nature13590

Fig. 4. RIG-I is required for control of reovirus infection.

Fig. 4

(a-c) ifit1 (a) or reovirus gene segment S4 genome expression ([b-c], right panel) and copy number per μg of RNA ([b-c], left panel) in reoT3D infected DCs (a-b) or control (RIG-I+/−) MDA5−/−, RIG-I−/−, and MDA5/RIG-I−/− MEFs. Mean of triplicate biological replicates (±s.d.) is shown. Cyclic-di-GMP was included as a control. **P≤0.01 (unpaired t-test). (d-e) Abundance of reovirus gene segment S4 determined as in (b) from intestine (d) and MLN (e) of mice following peroral infection with reovirus strain T3SA+. Data were pooled from two experiments. Each symbol represents an individual mouse. Line represents the mean of each group. *P<0.03 and **P<0.008 (unpaired t-test).