Table 1. Abnormalities in NM II ablated or mutated mice.
| Mouse Models | Lethality | Placenta | Heart | Brain | Others |
|---|---|---|---|---|---|
| A-/A- (ref. 14) | E6.5 | Disorganized visceral endoderm | |||
| AK5/AK5 (ref. 26) (Keratin 5-Cre) |
E9.5 to E13.5 | Reduced labyrinth vascularization | Hyperproliferative epidermis | ||
| APod/APod (ref. 96) (Podocin-Cre) |
Adult | Focal segmental glomerulosclerosis | |||
| APf4/APf4 (ref. 79) (Platelet Factor 4-Cre) |
Adult | Macrothrombocytopenia | |||
| B-/B- (refs. 19, 27, 35, 38) | E14.5 | No placenta defects | Reduced compact myocardium, Defective cardiac myocyte cytokinesis, VSD, DORV | Hydrocephalus, Defects in neuronal migration, Disrupted neuroepithelial cell-cell adhesion | |
| BαMHC/BαMHC (ref. 40) (αMHC-Cre) |
Adult | Cardiomyopathy, Disruption of intercalated discs | |||
| BNest/BNest (ref. 40) (Nestin-Cre) |
P14 | Hydrocephalus, Defects in neuronal migration, Disrupted neuroepithelial cell-cell adhesion | |||
| BDdx4/BDdx4 (ref. 97) (Germ Cell Ddx4-Cre) |
Adult | Male germ cell cytokinesis defects | |||
| C-/C- (ref. 36) | Adult | No obvious defects | |||
| B-C-/B-C- (ref. 36) | E14.5 | Reduced compact myocardium, Defective cardiac myocyte karyokinesis, VSD, DORV | Hydrocephalus, Defects in neuronal migration, Disrupted neuroepithelial cell-cell adhesion | ||
| Ba*/Ba* (ref. 20) (NM II-A replacing for II-B) |
E16.5 | Defective cardiac myocyte cytokinesis, VSD, DORV, (milder than B-/B- hearts) | Defects in neuronal migration, No hydrocephalus | ||
| Ab*/Ab* (ref. 15) (NM II-B replacing for II-A) |
E9.5 to E10.5 | Reduced labyrinth vascularization | Normal visceral endoderm | ||
| Aba/Aba (ref. 15) (NM II-B head/II-A rod chimera replacing for II-A) |
E9.5 to E10.5 | Reduced labyrinth vascularization | Normal visceral endoderm | ||
| Aab/Aab (ref. 15) (NM II-A-head/II-B-rod chimera replacing for II-A) |
E10.5 to E11.5 | Reduced labyrinth vascularization | Normal visceral endoderm | ||
| A+/AR709C (refs. 17 and 73) | Adult | Macrothrombocytopenia, Cataract, Focal segmental glomerulosclerosis | |||
| AR709C/AR709C (ref. 17) | E10.5 to E11.5 | Reduced labyrinth vascularization | Normal visceral endoderm | ||
| A+/AD1424N (ref. 17) AD1424N/AD1424N (ref. 17) | Adult | Macrothrombocytopenia, Cataract, Focal segmental glomerulosclerosis | |||
| A+/AE1841K (ref. 17) AE1841K/AE1841K (ref. 17) |
Adult | Macrothrombocytopenia, Cataract, Focal segmental glomerulosclerosis | |||
| B+/BR709C (ref. 43) | Adult | Diaphragmatic and umbilical hernia | |||
| BR709C/BR709C (ref. 43) | E14.5 to E16.5 | Reduced compact myocardium,ASD, VSD, DORV, No defects in cytokinesis | Defects in neuronal migration, No hydrocephalus | Major midline fusion defects: cleft palate, split lower sternum, large omphalocele |