Table 5. Comparison of homozygous 129MM in three IPD- E200K, IPD with 6-OPRI, and IPD with 8-OPRI.
| Homozygous 129MM | Compared PRNP mutation types | Mean difference, years (95% CI) | t statistics | P value |
|---|---|---|---|---|
| Age of onset | E200K and P102L | 12 (3.5, 20.5)e | 2.9 | 0.005* |
| E200K and 6-OPRI | 26.6 (18.6, 34.6)u | 8.1 | < 0.001* | |
| E200K and 8-OPRI | 31.6 (20.3,42.9)u | 9.6 | < 0.001* | |
| P102L and 6-OPRI | 14.6 (7.2, 21.9)u | 5.1 | < 0.001* | |
| P102L and 8-OPRI | 19.6 (8.7 30.5)u | 6.8 | < 0.001* | |
| 6-OPRI and 8-OPRI | 5.0 (-5.4, 15.5)e | 2.4 | 0.02 | |
| Disease duration | E200K and P102L | -3.9 (-7.1, -0.8)u | -7.5 | < 0.001* |
| E200K and 6-OPRI | -10.8 (-13.8, -7.9)u | -10.2 | < 0.001* | |
| E200K and 8-OPRI | -16.2 (-21.1, -11.3)u | -6.2 | 0.008 | |
| P102L and 6-OPRI | -6.9 (-9.9, -3.8)u | -5.8 | < 0.001* | |
| P102L and 8-OPRI | -12.2 (-17.2, -7.3)u | -4.6 | 0.02 | |
| 6-OPRI and 8-OPRI | -5.4 (- 10.2, -0.5)e | -2.1 | 0.05 |
e Equal variance, uunequal variance. *Significant P value, new α = 0.008 after Bonferroni correction.