Table 10.
Multivariable Cox Regression Modeling Analysis on Survival Disparities of Race/Ethnicity for Adenocarcinoma 1
| Model 1 3
|
Model 2 3
|
Model 3 3
|
Model 4 3
|
|
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Race/Ethnicity 4 | ||||
| White | Ref. | Ref. | Ref. | Ref. |
| Hispanic | 0.69 (0.44 to 1.09) | 0.86 (0.55 to 1.36) | 0.92 (0.58 to 1.47) | 0.88 (0.55 to 1.40) |
| Black | 1.01 (0.70 to 1.45) | 1.16 (0.81 to 1.67) | 1.33 (0.92 to 1.92) | 1.15 (0.79 to 1.68) |
| Gender | ||||
| Male | Ref. | Ref. | Ref. | |
| Female | 0.65 (0.52 to 0.81) | 0.90 (0.71 to 1.13) | 0.89 (0.71 to 1.13) | |
| Age at Diagnosis | ||||
| ≤ 49 | Ref. | Ref. | Ref. | |
| 49 to 65 | 1.46 (1.02 to 2.11) | 1.12 (0.78 to 1.62) | 1.10 (0.76 to 1.58) | |
| 65 to 75 | 2.16 (1.49 to 3.12) | 1.55 (1.07 to 2.25) | 1.44 (0.99 to 2.10) | |
| > 75 | 2.23 (1.53 to 3.24) | 1.75 (1.20 to 2.56) | 1.55 (1.06 to 2.28) | |
| Tumor Grade 2 | ||||
| Low | Ref. | Ref. | ||
| High | 3.17 (2.19 to 4.60) | 3.06 (2.09 to 4.46) | ||
| Tumor Size (mm) 2 | ||||
| ≤ 17 | Ref. | Ref. | ||
| 17 to 25 | 1.27 (0.82 to 1.97) | 1.26 (0.81 to 1.96) | ||
| 25 to 37 | 1.84 (1.21 to 2.80) | 1.69 (1.10 to 2.58) | ||
| > 37 | 1.87 (1.24 to 2.83) | 1.68 (1.10 to 2.55) | ||
| Extension 2 | ||||
| Intraglandular | Ref. | Ref. | ||
| Extraglandular | 2.26 (1.73 to 2.95) | 2.19 (1.67 to 2.88) | ||
| Metastatic | 4.73 (3.15 to 7.09) | 3.38 (2.22 to 5.15) | ||
| Lymph Nodes 2 | ||||
| No Involvement | Ref. | Ref. | ||
| Positive | 2.80 (2.11 to 3.71) | 2.76 (2.08 to 3.65) | ||
| Surgery | ||||
| Yes | Ref. | |||
| No | 3.14 (2.35 to 4.21) | |||
| Radiation | ||||
| Yes | Ref. | |||
| No | 0.94 (0.73 to 1.21) | |||
In Cox regression analysis, only patients with complete treatment characteristics were considered (N=1,593). Except for model 1 (crude model), diagnosis year was included into the models (not shown).
For carrying out the analyses for all models with the same number of patients, the patients with unknown tumor grade, tumor size, extension, or lymph nodes were included.
In the Cox regression models, no significant violation of the assumption of proportionality was detected. Therefore, in model 2 (patient characteristic), model 3 (patient and tumor characteristics), and model 4 (patient, tumor, and treatment characteristics), no stratified analyses were carried out.
The corresponding p values of hazard ratios (HR) on the disparity of Hispanic versus White (H/W) and Black versus White (B/W) were shown as follows. In model 1, H/W and B/W were 0.12 and 0.96, respectively; in model 2, H/W and B/W were 0.52 and 0.42, respectively; in model 3, H/W and B/W were 0.73 and 0.13, respectively and in model 4, H/W and B/W were 0.58 and 0.45, respectively.