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. Author manuscript; available in PMC: 2014 Oct 17.
Published in final edited form as: Drug Discov Today Dis Models. 2013 Jan 26;10(3):e145–e151. doi: 10.1016/j.ddmod.2012.11.003

Figure 1.

Figure 1

Biogenesis and function of microRNAs. After transcription in the nucleus, pre-miRNA molecules are released into the cytoplasm and can be processed further by Dicer to form the mature miRNA which is selectively recognized by RISC complex to regulate its target mRNA. In addition, recent findings have demonstrated that pre-miRNAs can be packaged and transported using exosomes and multivehicle bodies or other (not fully explored) pathways together with RNA-binding proteins.