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. 2014 Oct 1;4:58. doi: 10.1186/2045-3701-4-58

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© Qin et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Potential model for COUP-TFII function in tip and stalk cell specification during angiogenesis. COUP-TFII is preferably expressed in tip cells to ensure the inactivation of Notch signaling and activation of VEGFR-2 signaling during the sprout process. In stalk cells, Notch signaling and VEGFR-1 expression will be up-regulated due to the absence of COUP-TFII.