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. 2014 Sep 27;16(5):437. doi: 10.1186/s13075-014-0437-9

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© Krustev et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Laser speckle contrast analysis of the inflamed mouse knee joint. (A) Time course of the effect of locally administered URB597 (closed circles) vs. vehicle (open circles) on vascular perfusion. There was a significant reduction in local blood flow after URB597 administration, when compared to vehicle. P <0.0001; two-way ANOVA; n =6 to 7. (B) Dose-response profile for the effects of URB597 20 mins after administration. Local blood flow was significantly reduced by only low-dose URB597 (3.0 mg/kg). ^** P <0.01 one-way ANOVA with Dunnett’s post hoc test vs. vehicle; n =5 to 7. (C) Both AM251 (0.2 mg/kg) and AM630 (0.2 mg/kg) blocked the effect of URB597 (3.0 mg/kg) on blood flow in the inflamed mouse knee joint. Data are means ± SEM.^* P <0.05, one-way ANOVA with Bonferroni’s post hoc test vs. URB597 3.0 mg/kg; n =6 to 8. ANOVA, analysis of variance; SEM, standard error of the mean.

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