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. 2014 Oct 2;4:60. doi: 10.1186/2045-3701-4-60

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© Mao et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Enhanced activation of Akt-NF-κB pathways after LPS stimulation in Appl2 KO macrophages. Peritoneal macrophages derived from peritoneal cells were stimulated with 1 μg/mL LPS for 20 min. The cell lysates were analyzed by western blot. (A) Western blot analysis on peritoneal macrophages from APPL2 KO mice with the indicated antibodies. (B) The ratio values of p-Akt/Akt/β-actin, p-IKKβ/IKKβ/β-actin, p-IκB/ IκB/β-actin, p-p65/p65/β-actin as determined by the density analysis of (A) using NIH Image J software for relative values. *p < 0.05, compared with WT mice, n = 5.