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. 2014 Oct 2;4:60. doi: 10.1186/2045-3701-4-60

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© Mao et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The p85α subunit of PI3K associates with Appl 1 and 2. Peritoneal macrophages from WT mice were treated with 1 μg/mL LPS for 20 min. Macrophages lysates were immunoprecipitated with IgG, Appl2 and Appl1 antibody and immuoblotted using antibodies against TLR4, MyD88, Akt, p85α, Appl1 and Appl2, respectively.