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. 2014 Sep 30;16:449. doi: 10.1186/s13075-014-0449-5

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© Wu et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Multivariate stratified analyses for cancer occurrence between biologics cohort and biologics-naive cohort. All analyses were stratified according to age, gender, disease duration, average dosage of corticosteroids or disease-modifying anti-rheumatic drugs (DMARDs) after the index date, and coexisting comorbidities, based on a modified Cox proportional hazards model in the presence of a competing risk event. Some hazard ratios (HR) were not statistically significant due to a small number of cases. *Indicates average drug use after the index date of observation. Event, new cancer occurrence; MI, ischemic heart disease, including myocardial infarction; N, number; CVA, cerebrovascular attack.