Table 4.

DAVID functional annotation clusters of upregulated or downregulated mRNAs in at least four of five degenerative specimens

Annotation clusters	Cluster-related terms	Enrichment score
Most significant functional clusters for the mRNAs upregulated in at least four of the five degenerative samples
1	Nucleosome core, protein-DNA complex, chromatin assembly, et cetera	3.91
2	Glycosaminoglycan binding, polysaccharide binding, pattern binding, et cetera	3.89
3	Ribosome, translational elongation, cytosolic ribosome	3.63
4	Histone H2A	2.78
5	Basic-leucine zipper domain, DNA-binding region: basic motif	2.58
Most significant functional clusters for the mRNAs downregulated in at least four of the five degenerative samples
1	Negative regulation of gene expression, negative regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, et cetera	1.60
2	Cytosolic ribosome, ribosome, ribosomal subunit, et cetera	1.51
3	Phosphoglycerate mutase, Tele-phosphohistidine intermediate, Phosphoglycerate mutase, et cetera	1.49
4	Purine nucleotide biosynthetic process, purine nucleotide metabolic process, nucleotide biosynthetic process, et cetera	1.44
5	Proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, ubiquitin-dependent protein catabolic process, et cetera	1.40