Fig. 5.

FAS/FASLG upregulation in monocytes from PD patients. The expression of both FAS (a) and FASLG (b) is upregulated in unstimulated PD monocytes (Healthy controls n = 14, PD patients n = 14). c Monocytes are enriched in PD leukocyte cultures after 48 h treatment with FASLG-inhibitor APG101 (n = 15, APG 0.25 mg/ml). d Classical (CD14+CD16−) monocytes are decreased and non-classical (CD14−CD16+) monocytes are increased by treatment of PD leukocytes with APG101 in culture (n = 15). Bars represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001