Table 2.

Top 5 predicted upstream regulators in PD monocytes (ingenuity upstream analysis)

Upstream regulator	p value of overlap	Target molecules in dataset
Lipopolysaccharide	3.57E−37	ATF3, CCL2, CCL3, CCL4, CD83, CD9, COL1A2, COL6A1, CTSK, CXCL1, CXCL2, DCN, DKK3, DUSP1, DUSP2, EGR1, EGR2, FOS, FOSB, G0S2, GPR183, HCAR3, HLA-DQA1, IGFBP4, IL1B, IL8, JUN, KLF4, KLF6, MME, MMP2, MMP9, NFKBIA, NFKBIZ, NR4A1, NR4A2, OLR1, PLIN2, PMAIP1, PPP1R15A, PTGS2, RGS1, RHOB, SERPINH1, SLAMF7, SPARC, TGM2, TNC, TPM2, TRIB1, ZFP36
PDGF BB	3.22E−36	ATF3, CCL2, CXCL2, DCN, DUSP1, EGR1, EGR2, FHL1, FOS, FOSB, GPR183, IER2, IGFBP4, IL1B, IL8, JUN, KLF6, MMP2, MMP9, NR4A1, NR4A2, OLR1, PPP1R15A, PTGS2, RGS1, RHOB, SCD, TGM2, TNC, TRIB1, ZFP36
TGFB1	6.24E−31	CCL2, CCL3, CCL4, CD83, CLU, COL1A2, COL6A1, COL6A2, CTSK, CXCL1, CXCL2, DCN, DKK3, DUSP1, ECM1, EGR1, EGR2, EMILIN1, FHL1, FOS, FOSB, HLA-DQA1, IER2, IGFBP4, IL1B, IL8, JUN, KLF4, LTBP2, MMP2, MMP9, NFKBIA, NR4A1, NR4A2, OLR1, PTGS2, RGCC, RHOB, SCD, SERPINH1, SERTAD1, SPARC, TGM2, TNC, TPM2, ZFP36
LDL	4.04E−30	ATF3, CCL2, CCL3, CCL4, CTSK, CXCL2, DUSP1, DUSP2, EGR1, FOS, FOSB, G0S2, GPR183, IGFBP4, IL1B, IL8, JUN, MMP2, MMP9, NR4A1, NR4A2, OLR1, PLIN2, PMAIP1, PTGS2
FAS	1.10E−29	CCL2, CCL3, CCL4, CD83, COL1A2, COL6A1, CXCL1, CXCL2, DUSP10, EGR1, EGR2, FOS, FOSB, GPNMB, HCAR3, IL1B, IL8, JUN, MME, MMP9, NFKBIA, NR4A1, NR4A2, PLIN2, PPP1R15A, TNC, TRIB1, ZFP36