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. 2014 Nov;21(11):627–633. doi: 10.1101/lm.035816.114

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© 2014 Kwon et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — ChR2-expression in the auditory pathways projecting from auditory thalamus and cortex to the LA. (A) AAV constructs expressing ChR2-Venus or control EGFP. (B) AAV viruses were injected into ipsilateral MGm and AuV, which directly project to the LA. (C) ChR2-Venus expression was observed in the auditory thalamus (right) and cortex (left) with reciprocal projections from each other. Single injections of AAV-EGFP into either AuV or MGm specifically yielded infected neurons without reciprocal axonal projection (top insets). ChR2-Venus expression was detected on the membranes of infected neurons (bottom insets). (D) Amygdala showed ChR2-Venus expression representing axonal projections and terminals from auditory afferents. (E) Fluorescence in amygdala subdivisions was analyzed in the dorsal and ventral LA, BA, and CE (n = 10). Data are expressed as mean ± SEM. (***) P < 0.001, (*) P < 0.05. (Au1) Primary auditory cortex, (AuV) ventral part of secondary auditory cortex, (MGm/PIN) medial division of medial geniculate/posterior intralaminar nucleus, (LAd) dorsal part of lateral amygdala, (LAv) ventral part of lateral amygdala, (BA) basal amygdala, (CE) central amygdala, and Base is background fluorescence measured in piriform cortex.