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. 2014 Sep 13;29(6):447–455. doi: 10.1093/mutage/geu041

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© The Author 2014. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Fig. 7. — (A) FISH using whole chromosome paints for 1, 4 and 8 on human metaphase spreads. Chromosome painting probes were directly labeled with Texas Red (Chromosome 1) and FITC (Chromosome 4 and 8). (B) Detection of chromosomes 1, 4 and 8 in cytokinesis blocked MN in ex vivo γ-rays-irradiated peripheral blood lymphocytes of donor 2 (top panel) and donor 3 (bottom panel). (C) Detection of chromosome 1 in IR-induced micronuclei in donor 2 using whole chromosome painting probe (red colour) and centromere-specific probe (green colour). (D) Detection of chromosome 1 (red colour) and 4 (green colour) in IR-induced nucleoplasmic bridges (arrowheads). Chromosome 1 fragment is indicated by the arrow.