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. Author manuscript; available in PMC: 2015 Sep 9.
Published in final edited form as: Int Arch Allergy Immunol. 2014 Sep 9;164(4):271–279. doi: 10.1159/000365633

Table 1.

Phenotypic differences in the lupus-like disease model of FcγRIIB-/- and FcγRIIB-/-.Yaa mice that express the IgE locus or not.

lgE+ IgE-
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Kidney ACR 0.5 1.3 0.1 0.5
C3 ++ ++ - -
IgG + ++ - -
Nephritis score 6 10 - 1
Serum dsDNA IgG ++ + + -
RNP IgG + ++ - -
Histones IgG ++ + - -
SLO Size Hypertrophy Hypertrophy Normal Normal
CD138+ cells ↑ ↑↑ Normal ↑
CD19+ B220+ cells ↑ ↑↑ Normal Normal
CD11b+ CD11c+ cells ↑ ↑↑ Normal Normal
Ly6Clo-int cells ↑↑ ↑↑ Normal Normal
Ly6Chi cells ↑↑ ↑↑ Normal Normal
Neutrophils cells ↑↑ ↑↑ Normal Normal
CD200R+ basophils ↑ ↑↑ Normal Normal
Average Life spam (months) 7.3 4.8 >12 11

ACR: albumin/ creatinine ratio: C3: complement 3: CD: cluster of differentiation; RNF: nbonucleoproteins