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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Immunol. 2014 Sep 22;193(9):4368–4380. doi: 10.4049/jimmunol.1400876

FIGURE 1. Modest reduction in CTLA4 accompanied by a permissive MHC locus was sufficient to induce T1D in mice at juvenile age.

FIGURE 1

(A) CTLA4RNAi mice on the B6.H2g7 background and transgene-negative B6.H2g7 littermate controls were monitored for diabetes for 60 days. (B) Diabetes incidence in juvenile male and female CTLA4RNAi/B6.H2g7 mice. (C) Representative H&E sections of the pancreas from 19 day old mice (original magnification: x12.5). (D) Summary of islet infiltration in CTLA4RNAi/B6.H2g7 or transgene-negative B6.H2g7 littermate controls (n=5 per group). (E) Representative H&E sections of the pancreas from sex-matched 12–13 week old CTLA4RNAi or PL4 vector control mice on the diabetes-resistant B6 background (original magnification: x12.5). (F) Summary of islet infiltration in 10–27 week old CTLA4RNAi/B6 or PL4 vector control mice (age- and sex-matched, n=6 per group). Each bar represents one animal. *p<0.05; ***p<0.005; ns, not significant.