Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Immunol. 2014 Sep 22;193(9):4368–4380. doi: 10.4049/jimmunol.1400876

FIGURE 4. Little impact of a modest reduction of CTLA4 on CD8+ T cell memory in the target tissue.

FIGURE 4

(A) Flow cytometry analyses of the naïve, TCM, TEFF and TEM subsets of the conventional CD8+ T cell compartment in the pancreas and PLN (numbers represent percentages of gated CD8+ population). (B–D) Frequencies and total cell numbers of CD8+ TEM (B), CD8+ TEFF (C) and CD8+ TCM (D) subsets impacted by CTLA4RNAi on the B6.H2g7 background. Control mice were transgene-negative littermates (n=6 per group, 4–12 week old). Each data-point represents one animal (Mean ± SEM). ns, not significant.