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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Acta Neuropathol. 2014 Jul 6;128(5):639–650. doi: 10.1007/s00401-014-1314-y

Fig. 1. Transportation of α-synuclein from the brain to blood.

Fig. 1

Mice were intracerebroventricularly injected with 125I-labeled α-synuclein. (a) Brain and blood plasma were then collected at 2, 5, 10, 20 and 60 min after injection. Levels of radioactivity in the brain and the plasma were determined using a gamma counter. (b) Blood was collected at 60 min after injection, followed by L1CAM-containing exosome extraction from platelet-free plasma. Levels of radioactivity were measured in the whole plasma, the exosome fraction (Exo), and the exosome-less fraction (supernatant after immunoaffinity capture; Super). Data shown are mean ± S.D. from 5 mice. CPM, counts per minute.