Figure 4. Binding of a type II NKT TCR to mCD1d/LPC complexes.
(A) Sensograms showing mCD1d-LPC complexes binding to the Hy19.3 TCR. The association and dissociation constants measured show a slightly higher binding affinity of this ligand for the TCR, compared to mCD1d-LSF complexes. (B) Affinity measurements for the lysophospholipid variants measured for this study. Average and SEM of two independent measurements are reported.