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. 2014 Sep 24;193(9):4590–4601. doi: 10.4049/jimmunol.1401781

FIGURE 5.

FIGURE 5.

Complement opsonization of HIV-1 suppressed TLR8 activation in DCs. DCs (1 × 106/ml) were pretreated with the weak base NH4Cl, the TLR8 specific inhibitory oligonucleotide IRS957, or control before exposure to an MOI of 8 for F-HIV or C-HIV or were mock treated for 6 h. mRNA levels of IL-1β and MxA for DCs pretreated with NH4Cl (A and B) or IRS957 (C and D) were assessed by qPCR. Values have been normalized with mock values set to 1, and data are shown as means ± SEM of three to eight independent experiments. *p < 0.05.