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. 2014 Sep 24;193(9):4590–4601. doi: 10.4049/jimmunol.1401781

Table II. Protein expression of inflammatory and antiviral factors in DCs 24 h after exposure to F-HIV, C-HIV, or CI-HIV.



F-HIV
C-HIV
CI-HIV
Inflammatory factors
 CCL5 C-C motif chemokine 5 2.40* 1.40 1.50
 CCL17 C-C motif chemokine 17 2.60* 1.63 2.10
 CCL22 C-C motif chemokine 22 1.73 1.33 1.83
 EBI3 IL-27 subunit β 4.33* 3.93 4.17
 CD40 TNFR superfamily member 5 2.27 1.63 1.63
 TRAF1 TNFR-associated factor 1 5.40* 3.87 4.07
 TNFAIP2 TNF-α–induced protein 2 3.83* 2.50 2.13
 NFKB1 NF-κB p105 subunit 2.27* 2.07* 2.10*
 NFKB2 NF-κB p100 subunit 2.33* 2.07* 2.09*
Antiviral factors
 MX1 IFN-induced GTP-binding protein Mx1 7.83* 4.50 3.40
 MX2 IFN-induced GTP-binding protein Mx2 4.83* 2.90 2.20
 GBP1 IFN-induced guanylate-binding protein 1 2.83* 1.90 1.43
 GBP2 IFN-induced guanylate-binding protein 2 1.8* 1.43 1.23
 IFIT1 IFN-induced protein with tetratricopeptide repeats 1 5.77* 2.97 2.50
 IFIT2 IFN-induced protein with tetratricopeptide repeats 2 6.07 3.90 2.97
 IFIT3 IFN-induced protein with tetratricopeptide repeats 3 7.33* 4.47 3.40
 IFIT4 IFN-induced protein with tetratricopeptide repeats 4 2.65 1.80 1.55
 PKR IFN-induced, dsRNA-activated protein kinase 3.17 1.70 1.57
 IFIH1 Isoform 1 of IFN-induced helicase C domain–containing protein 1 3.97* 2.43 1.90
 ISG15 Ubiquitin-like protein ISG15 15.73* 8.9 6.00

DCs (1 × 106/ml) were exposed to an MOI of 8 of F-HIV, C-HIV, or CI-HIV or were mock treated for 24 h and expression of proteins associated with inflammatory and antiviral responses was determined by mass spectroscopy proteomics. Values have been normalized with mock set at 1 and are shown as the mean fold increase compared with mock of three independent experiments.

*p < 0.05 upregulation compared with mock.