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Structure of human c-Myc protein. The C-terminal domain (CTD) of c-Myc is pivotal for the association with MAX, a basic-helix-loop-helix (HLH)-leucine zipper (L Zip)-interacting protein. The N-terminal transactivation domain (NAD) consists of three elements, Myc box-I, II, III (MBI, MBII and MBIII), which are the regulatory motifs necessary for c-Myc functions.
