Skip to main content
. 2014 Sep 21;10(10):1108–1115. doi: 10.7150/ijbs.9797

Figure 5.

Figure 5

A: The effects of GF109203X on dexmedetomidine (DMT)-induced c-Jun NH2-terminal kinase (JNK) phosphorylation (N = 4) in rat aortic vascular smooth muscle cells (VSMCs). VSMCs were treated with 10-6 M DMT alone for 10 min or with 10-6 M DMT for 10 min after pretreatment with 10-5 M GF109203X for 1 hr. JNK phosphorylation was examined by western blot analysis as described in the Methods section. The data are presented as the mean ± SD. N indicates the number of independent experiments. p-JNK: phosphorylated JNK. t-JNK: total JNK. *P < 0.05 versus the control. †P < 0.01 versus 10-6 M DMT alone. B: The effect of DMT on protein kinase C (PKC) phosphorylation (N = 4) in rat aortic VSMCs. VSMCs were treated with 10-6 M DMT alone for 10 min. PKC phosphorylation was examined by western blot analysis as described in the Methods section. The data are presented as the mean ± SD. N indicates the number of independent experiments. p-PKC: phosphorylated PKC, t-PKC: total PKC. *P < 0.05 versus the control.