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. 2014 Oct 2;10(10):1116–1127. doi: 10.7150/ijbs.10236

Figure 6.

Figure 6

NE tumors may be derived from intermediate progenitor cells expressing SV40-T antigen. A. Double immunostaining for Syp (green) and SV40-T antigen (red) in the prostate tissue section of an 8-week-old 3PEKOT mouse. Arrows indicate immunostaining signals for Syp or SV40-T. B. Double immunostaining for SV40-T (green) and K5 (red) in a prostate tissue section of a 3PEKOT mouse. Arrows indicate the same cell positive for SV40-T, K5 and DAPI staining. C. Double immunostaining for Syp (green) and SV40-T (red) in a prostate tissue section of a 3PEKOT mouse. Arrows indicate double positive cells in the cluster of NE cells. D. Double immunostaining for Syp (green) and K5 (red) in the prostate section of a 3PEKOT mouse. Arrows indicate the double positive cells. E. Double immunostaining for Syp (green) and p63 (red). Arrows indicate the Syp+ cell with weak p63 immunoreactivity. F. Triple immunostaining for Syp (green), SV40-T (red) and K5 (blue) in a prostate section of 12-week-old 3PEKOT mouse. Arrows indicate the triple positive cells. G. Double immunostaining for K5+ BCs and Syp+ NE tumor cells in a prostate of 30-week-old 3PEKOT mouse with a large NE tumor.