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. 2014 Oct;28(10):4408–4419. doi: 10.1096/fj.14-253971

Figure 6.

Figure 6.

TFAM ablation in adipose tissue triggered hypertension and cardiac dysfunction. A) Systolic and diastolic blood pressure of male control (Lox) and adipo-TFAM-KO (KO) male mice at 24 wk of age. B) LV heart weight of male Lox and KO mice at 24 wk of age, normalized either to body weight (BW; mg/g) or tibialis (TB) length (mg/ml). Data are means ± sem of 6–8 samples/genotype. *P < 0.05. C) Expression levels of TFAM, fibrosis marker (Col1a, col3a1, and CTGF), and heart failure marker (BNP, ANP, and SKMα) mRNAs were compared by using qPCR in heart tissue of male Lox and KO mice at 24 wk of age. Data are means ± sem of 6 samples/genotype. *P < 0.05. D) Representative sections of heart tissue from 24-wk-old male Lox and KO mice, stained with Masson's trichrome. E) Expression levels of IL6 and TNF-α mRNA in heart of male Lox and KO mice at 24 wk of age, compared by qPCR. Data are means ± sem of 6 samples/genotype. *P < 0.05. F) AGTN mRNA level, assessed by qPCR, in iWAT, eWAT, and liver of male Lox and KO mice at 24 wk of age. Data are means ± sem of n = 6/genotype. *P < 0.05. G) Circulating level of Ang II in male Lox and KO mice at 24 wk of age. Data are means ± sem of n = 10/genotype. *P < 0.05.