Figure 5. Negative prognostic value of extramedullary soft tissue lesions.

Display of three patients without (A) and with (B; C) extramedullary myeloma manifestations. Whereas patient A had exclusively intramedullary lesions, patients B and C presented with intramedullary and extramedullary disease. Patient B had mainly iliac lymph node involvement (arrow), patient C suffered from muscle manifestations (arrow). All patients received chemotherapy with novel agents after ¹⁸F-FDG-PET/CT; follow-up was 8 months in all. Whereas patients A and B have not progressed yet, patient C died 8 months after the PET scan. EMD = extramedullary disease, LN = lymph node, TTP = time to progression