Figure 5. Lipo-DS inhibited growth of BC xenografts.

MDA-MB-231 cells (1×10⁶) were subcutaneously injected at one rear flank of the mice. When the tumor volume reached ~200mm³, the tumor bearing mice were randomly subdivided into 5 groups (8 mice/group) e.g. control; DS 75mg/kg p.o + CuGlu 8mg/kg p.o; CuGlu 8mg/kg p.o; Lipo-DS 75mg/kg i.v; Lipo-DS 75mg/kg i.v + CuGlu 8mg/kg p.o. The drugs were administered 3 times/week for successive 3 weeks. A. Growth curves of tumor size. Arrows represent drug administration. B. The effect of different treatments on tumor weight after 28 days observation. C. The effect of different treatment on Ki67 and TUNEL expression (×400 magnification). D. The effect of different treatments on BAX and Bcl-2 expression. E. Histo-pathological images of vital organs (H&E staining, 400 magnification).