Table 1. Cytotoxicity of conventional anticancer drugs in BC cell lines.
| MCF7 | T47D | |||||
|---|---|---|---|---|---|---|
| dFdC | Dox | PTX | dFdC | Dox | PTX | |
| ATT | 28.7 (7.6) | 17.1 (1.1) | 6.3 (1.6) | 76.3 (5.7) | 64.2 (2.4) | 7.7 (2.4) |
| MSC | >1000 | >2000 | >1000 | >1000 | >2000 | >1000 |
| SUS | >1000 | >2000 | >1000 | >1000 | >2000 | >1000 |
| Hypo | >1000 | >2000 | >1000 | >1000 | >2000 | >1000 |
| Mock | 14.8 (5.2) | 63.2 (12.9) | 2.8 (0.4) | 2.5 (2.0) | 169.8 (42.5) | 6.2 (1.8) |
| C2 | >1000 | 424.3** (65.5) | >1000 | N/A | N/A | N/A |
| P1 | >1000 | 159.8** (36.8) | >1000 | N/A | N/A | N/A |
| C1 | N/A | N/A | N/A | >1000 | 498** (130) | >1000 |
| C3 | N/A | N/A | N/A | >1000 | >1000 | >1000 |
The figure represents IC50 value from three MTT experiments [mean (SD)]. The cells were exposed to drugs for 72 hours. ATT: attached cells; MSC: mammosphere cells; SUS: suspension culture in normal medium; Hypo: hypoxic culture (O2 < 1%). Mock: Empty vector transfected cells; C2, P1, C1, C3: NFκB p65 transfected clones. ** p<0.01 (n=3) compared with Mock cells.