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. 2014 Jul 31;5(17):7651–7662. doi: 10.18632/oncotarget.2287

Fig.4. LNA-mediated miRNA inhibition enhances glioma cell susceptibility to immune cell lysis.

Fig.4

A, B. LAK cells were used in a 3.5 h immune cell lysis assay with LNT-229 (A) or LN-308 cells (B), pretreated with control or LNA 93 molecules for 48 h, as target cells. Data are expressed as specific lysis at different effector:target (E:T) ratios for independent experiments (* p<0.05, ANOVA). C. LNT-229 cells were exposed to miR-93 mimics (mimic-93) or the respective control molecules and subsequently used as target cells in an immune cell killing assay as in (A). D. LAK cells were pre-incubated with anti-NKG2D antibody or isotype control for 1.5 h and subsequently used as effector cells in a killing assay as in (A) against LNT-229 target cells pre-exposed to LNA 93 or miR-93 mimic at an E:T ratio of 20:1. Data are expressed as % of lysis of cells treated with control LNA plus isotype antibody (* p<0.05, n.s.= not significant).