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. 2014 Aug 4;5(17):7820–7832. doi: 10.18632/oncotarget.2309

Figure 3. Effects of neddylation inactivation on the growth of cholangiocarcinoma cells.

Figure 3

(A and B) Effects of MLN4924 on the in vitro viability of QBC939 and RBE cells. Cells were treated with the indicated concentrations of MLN4924 for 96 hours and viability was assessed by ATPlite and CCK-8 assays respectively. N = 3 ± SD. (C) Impact of MLN4924 on clonogenic survival. QBC939 and RBE cells were treated with indicated concentrations of MLN4924 for 12 days. N = 3 ± SD. (D) Effects of MLN4924 and cisplatin on the in vitro viability of QBC939 and RBE cells. Cells were treated with 0.1μM MLN4924, 0.25 μM cisplatin or both agents for 96 hours. N = 3 ± SD. *, P<0.05; **, P<0.01; ***, P<0.001.