Table 5. Genes identified through analysis with DU-145 cells that showed significant increased methylation in Gleason score 8 vs Gleason score 6 prostate cancer tumors.
| Gene Symbol | Gene Name | CpG Location | Fold Change | p-value |
|---|---|---|---|---|
| ACTA1 | actin, alpha 1, skeletal muscle | Intragenic | 3.026 | 0.0007 |
| TBX3 | T-box 3 | Intergenic | 2.939 | 0.0016 |
| HOXD3 | homeobox D3 | Intragenic | 2.124 | 0.0026 |
| VAX1 | ventral anterior homeobox 1 | Intragenic | 3.679 | 0.0051 |
| TBX15 | T-box 15 | Intragenic | 3.155 | 0.0102 |
| HOXD8 | homeobox D8 | Promoter | 2.043 | 0.0124 |
| HOXB6 | homeobox B6 | Intragenic | 2.165 | 0.0174 |
| FOXD2 | forkhead box D2 | Promoter | 2.030 | 0.0243 |