Figure 1. Fucoidan inhibits tumorigenesis in LLC1 cell-xenograft male C57BL6 mice.

LLC1 cells (2 × 10⁵) were inoculated into the hypodermic dorsum of male C57BL6 mice. Beginning on the seventh day, the mice were orally fed with ddH₂O (control) and 48/96/144 mg of fucoidan per kg for 21 days at 7 oral feedings/week/mouse. (A) The tumor volume was measured, and (B) tumor samples from the mice were collected at the end of treatment. (C) The tumor weight and (D) mouse weight were also measured. (E) The TGFR protein levels of the tumor lesions were assessed. Western blot analysis was performed to determine the TGFR protein levels. Two of five individual experiments are presented. Each bar represents the mean ± SEM. Significant differences are shown (*P < 0.05 and ***P < 0.005, compared with the control group).