Scheme 2.
Syntheses of azepane-based PTCs 3. a) SOCl2, Et3N, CH2Cl2, 25 °C b) TMSCN, SnCl4, 25 °C, 47–63% (over two steps) c) LiAlH4, mesitylene, reflux, 29–43% d) Br-Y-Br, K2CO3, CH3CN, reflux, 49–69%.
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