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. Author manuscript; available in PMC: 2014 Oct 20.
Published in final edited form as: Org Biomol Chem. 2011 Oct 31;10(2):251–254. doi: 10.1039/c1ob06573d

Table 2.

Scope of the α-alkylation of 7 using different electrophiles

graphic file with name emss-60687-t0004.jpg
Entry RBr Electrophile Product Yielda (%) ee (%)b (Conf.)c
1 PhCH2Br 8 9 81 87 (S)
2 graphic file with name emss-60687-t0005.jpg 10 11 83 76 (S)
3 graphic file with name emss-60687-t0006.jpg 12 13 80 85 (S)
4 graphic file with name emss-60687-t0007.jpg 14 15 79 80 (S)
5 graphic file with name emss-60687-t0008.jpg 16 17 79 93 (S)
6 graphic file with name emss-60687-t0009.jpg 18 19 71 78 (S)
a

Isolated yields

b

Determined by HPLC using a chiral stationary phase.

c

Determined by comparison of the HPLC retention time and optical rotation with literature values.6,9,20