Skip to main content
. 2014 Oct 20;4:6683. doi: 10.1038/srep06683

Figure 4. Linifanib induces autophagy by inhibiting the phosphorylation of PDGFR-ß, Akt/mTOR and Mek/Erk signaling.

Figure 4

(A) & (B). Immunoblotting for phospho- or total PDGFR-ß, Akt, mTOR, S6K, Mek and Erk in cells treated with linifanib for 24 h. (C). Immunoblotting for LC3, p62, Beclin-1, ATG5 and ATG7 in cells transfected with siRNA against PDGFR-ß. (D). Quantification of PDGFR-ß in cells transfected with siRNAs. Data were expressed as the mean ± SD. ** P<0.01.