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. 2014 Nov;95(Pt 11):2523–2530. doi: 10.1099/vir.0.066886-0

Fig. 3.

Fig. 3.

Sensitivity to LAM. (a) HepG2 cells were transiently transfected with HBV constructs as indicated. LAM was added to the culture medium at different concentrations as indicated. Replicative intermediates of HBV were determined as a measure of HBV replication. One representative experiment is shown. (b) Quantification of HBV replicative intermediates after incubation with 1 and 10 µM LAM. Means and sd are based on three independent experiments; values are given relative to incubation without LAM. (c) Quantification of extracellular HBV virions from supernatant 4 days after transient transfection of HBV constructs and after PEG precipitation of secreted virions; values are given relative to incubation without LAM. RC, Relaxed circular; RI, replicative intermediates.