Genomic organization showing the ORFs and conserved protein domains of fesavirus-1 and -4, and other RNA viruses with related genomic organization. CPro, cysteine protease; S3H, superfamily 3 helicase. CrPV, cricket paralysis virus; RHDV, rabbit haemorrhagic disease virus; SJNNV, striped jack nervous necrosis virus. Fesavirus-1 and -4 in this study are marked with arrows.