Figure 1.

Timeline of study visits for 20 women over 1 menstrual cycle arranged from lowest to highest number of HIV-1 RNA detection episodes. Visits occurred twice weekly for 3 weeks following the week of menses and are numbered sequentially by order of time since preceding menses (visits 1–6). Cycle duration was defined as the duration from onset of menses until the onset of the next menses according to self-report. Follicular phase (blue) was determined as visits occurring between the end of menses and the start of the rise in serum progesterone. Luteal phase (green) was determined as any remaining days of the cycle until the onset of the next menses. Genital tract HIV-1 RNA detection (▴), genital HIV-1 DNA detection (•), plasma HIV-1 RNA detection <50 copies/mL / quantification ≥50 copies / mL) (▪)/□) are depicted for each study visit. Abbreviation: HIV, human immunodeficiency virus. ^a Menses began before study completion, so some visits occurred outside study window. ^b Did not have a rise in serum progesterone during the study period. Follicular phase was instead defined as visits occurring >14 days before the onset of the next menses. ^c Treated for symptomatic trichomonas infection on visit 5. ^d Treated for symptomatic vaginal yeast infection on visit 3. ^e Was receiving hormonal contraception (depot medroxyprogesterone acetate). ^f Completed only 5 study visits. -- indeterminate result.