Table 2.
Differential expression of chicken genes on infection with avian metapneumovirus.
| Transcription Fold Change | |||||
| Gene Accession No. | Description | 2.5 h | 24 h | 48 h | 96 h |
| SWP:MX_CHICK | Interferon-induced GTP-binding protein Mx* | NC | 14.20 | 38.63 | 61.38 |
| SWP:INI2_PANTR | Interferon-induced protein 6-16 precursor* | NC | 17.39 | 13.87 | 30.64 |
| SWP:IFT1_HUMAN | Interferon-induced 56 kDa protein* | 6.89 | 32.28 | 19.70 | 20.90 |
| EMB:AAH04977 | Interferon-induced protein with tetratricopeptide repeats 4* | 4.38 | 12.60 | 18.67 | 6.63 |
| SWP:STA1_HUMAN | Signal transducer and activator of transcription 1-α/β* | NC | 16.36 | 33.77 | 54.86 |
| SWP:IFT5_HUMAN | Retinoic acid and interferon-inducible 58 kDa protein (RI58) | 2.80 | 31.19 | 28.30 | 22.23 |
| EMB:Q9QXH3 | α.interferon-inducible protein P27_H* | NC | 15.28 | 12.19 | 23.67 |
| SWP:EMF1_CHICK | CXC chemokine 9E3 (Human IL-8 homolog)* | 2.39 | 7.30 | 39.32 | 53.84 |
| EMB:O73912 | CXC chemokine K60* | 2.01 | 2.43 | 18.64 | 18.33 |
| EMB:O35131 | Complement C3F* | NC | 2.24 | 10.03 | 12.91 |
| SWP:PRSX_SPETR | 26S Protease regulatory subunit S10B | NC | NC | 2.37 | 2.21 |
| SWP:UBPI_HUMAN | Ubiquitin carboxyl-terminal hydrolase 18 (Ubp)* | 2.13 | 11.94 | 6.23 | 11.83 |
| EMB:AAH01874 | Similar to sequestosome 1* | 2.01 | NC | 2.29 | 7.78 |
| SWP:CUL1_MOUSE | Cullin homolog 1 (CUL-1)* | NC | NC | NC | 2.13 |
| EMB:O88544 | COP9 Complex subunit 4 | NC | NC | 2.00 | 2.20 |
| EMB:Q9Y4Z6 | Vacuolar protein sorting (Vps45) | NC | NC | 5.18 | 4.44 |
| EMB:Q9D872 | Signal recognition particle receptor B subunit | NC | NC | NC | 2.30 |
| EMB:Q9JMJ6 | Syntaxin 7 | NC | NC | 2.04 | 3.42 |
| EMB:Q9Y5P9 | Endocytic receptor ENDO 180 | NC | 2.38 | 3.06 | 4.33 |
| SWP:CLH1_HUMAN | Clathrin heavy chain 1 (CLH-17) | NC | NC | NC | 2.82 |
| EMB:O42404 | CD80-like protein precursor* | NC | NC | 2.68 | 4.67 |
| SWP:TMF1_HUMAN | TATA element modulatory factor (TMF)* | NC | NC | 3.24 | 4.83 |
| SWP:PTB_PIG | Polypyrimidine tract-binding protein (PTB) | NC | NC | NC | 2.48 |
| EMB:O95320 | U5 SNRNP-specific 40 kDa protein | NC | NC | 4.58 | 7.16 |
| EMB:Q9WVG7 | Odd-skipped related 1 protein | NC | -1.89 | -2.15 | -2.02 |
| SWP:IF37_MOUSE | Translation initiation factor 3 subunit (eIF-3) | NC | 2.03 | 5.18 | 6.45 |
| SWP:RL3_BOVIN | 60S ribosomal protein L3 | NC | NC | 9.22 | 11.15 |
| SWP:PDI_CHICK | Protein disulfide isomerase (PDI) | NC | NC | -2.32 | -2.11 |
| SWP:IF2P_HUMAN | Translation initiation factor 2 (IF-2) | NC | -2.20 | -3.20 | NC |
| EMB:Q9PTD6 | Ribosomal protein S6 | NC | NC | -3.00 | -1.87 |
| SWP:RL5B_XENLA | 60S ribosomal protein L5B | NC | NC | -2.67 | -2.54 |
| SWP:EF1A_CHICK | Elongation factor 1-alpha 1* | NC | NC | -2.46 | NC |
| SWP:NPM_CHICK | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) | NC | NC | -2.18 | NC |
| SWP:QSP_CHICK | Quiescence-specific protein precursor (P20K) | NC | 3.97 | 5.02 | 7.92 |
| SWP:DIA_DROME | Diaphanous protein | NC | NC | -2.06 | NC |
| EMB:Q9U9S7 | Adenylyl cyclase | 2.18 | 8.91 | 9.47 | 16.52 |
| EMB:O08623 | PKC-Zeta-interacting protein (ZIP) | NC | NC | 2.41 | 6.76 |
| SWP:RSFR_CHICK | Ribonuclease homolog precursor (RSFR) | NC | NC | NC | 2.54 |
| SWP:SSGP_VOLCA | Sulfated surface glycoprotein 185 (SSG 185) | 2.22 | 20.78 | 16.18 | 40.35 |
| SWP:N107_HUMAN | Nuclear pore complex protein NUP107 | NC | NC | 2.23 | 2.08 |
| A partial list of the genes exhibiting change in transcription by a factor ≥ 2 in aMPV infected compared to un-inoculated control cells is shown. The sequence accession numbers (SwissProt, EMBL databases), gene names, and fold change in transcription at 2.5, 24, 48, and 96 hours post-infection are listed. The time course experiment was repeated twice and the hybridization with fluorescent-labeled probe was repeated twice per infection experiment. Transcription fold change values are the average of Cy5 to Cy3 ratios of the replicates from four experiments. NC: no change. | |||||