Table 2.
Genes Belonging to the GO Categories Sex Determination (det) and Sex Differentiation (diff) Overexpressed in Ovaries/Female Tissues in All Four Investigated Species
| Ovary/Female Overexpressed Genes in All Four Species | GO Term | Overexpressed In |
|---|---|---|
| Apoptosis regulator bax (accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2)a | Sex diff | Ovary |
| Bcl-2-related ovarian killer protein (induces apoptosis) | Sex diff | Ovary/females |
| Beta-n-acetylglucosaminyltransferase lunatic fringe-like (initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules) | Sex diff | Ovary/females |
| Bone morphogenetic protein receptor type-1a (receptor for BMP-2 and BMP-4, regulates transcription) | Sex diff | Ovary |
| Bone morphogenetic protein 15 (TGF-beta family member, oocyte-specific growth/differentiation stimulating folliculogenesis and granulosa cell growth) | Sex diff | Ovary |
| Cbp p300-interacting transactivator 3-like (stimulates estrogen-dependent transactivation activity, positively regulates TGF-beta signaling) | Sex det/diff | Ovary/females |
| Doublesex- and mab-3-related transcription factor 2 (dm-family, could be implicated with gonadal dysgenesis and XY sex reversal in humans) | Sex det/diff | Ovary/females |
| Ensconsin (microtubule-stabilizing protein) | Sex diff | Ovary/females |
| Forkhead box l2 (transcriptional regulator, in mammals critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination) | Sex det/diff | Ovary |
| Forkhead box protein o3 (transcriptional activator, triggers apoptosis) | Sex diff | Ovary/females |
| Frizzled-10 (G protein-coupled Wnt receptor, positive regulator of the Wnt/beta-catenin pathway) | Sex diff | Ovary/females |
| g1 s-specific cyclin-d1 (regulation of cell-cycle during G1/S transition) two gene copies OE in ovary | Sex diff | Ovary/females |
| Hepatocyte growth factor receptor (receptor tyrosine kinase, transduces signals from the extracellular matrix into the cytoplasm, regulates many physiological processes) | Sex diff | Ovary |
| Inhibitor of growth protein 2 (possibly involved in apoptotic pathways) | Sex diff | Ovary/females |
| Mothers against decapentaplegic homolog 5 (transcriptional modulator activated by BMP type 1 receptor kinase) | Sex diff | Ovary |
| Mothers against decapentaplegic homolog 9 (transcriptional modulator activated by BMP type 1 receptor kinase) | Sex diff | Ovary/females |
| Peroxisomal multifunctional enzyme type 2 (peroxisomal beta-oxidation pathway for fatty acids) | Sex diff | Ovary |
| Prohibitin (inhibits DNA synthesis, regulates proliferation) | Sex diff | Ovary |
| Ribonucleoside-diphosphate reductase large subunit (DNA synthesis) | Sex diff | Ovary/females |
| Sal-like protein 1 (zinc-finger transcription factor, transcriptional repressor involved in organogenesis) | Sex diff | Ovary |
| Secreted frizzled-related protein 2 (modulator of Wnt signaling) | Sex diff | Ovary |
| Secreted frizzled-related protein 3 (modulator of Wnt signaling) | Sex diff | Ovary/females |
| Sox3-like (transcription factor required during the formation of the hypothalamo-pituitary axis, male sex determiner in mammals) | Sex det/diff | Ovary/females |
| Tcdd-inducible poly [ADP-ribose] polymerase (possibly role in the adaptive response to chemical exposure, response to DNA strand breaks) | Sex diff | Ovary |
| Transcription factor ap-2 gamma (DNA-binding protein interacting with inducible viral and cellular enhancer elements to regulate transcription) | Sex diff | Ovary/females |
| Tyrosine-protein phosphatase nonreceptor type 11 (acts downstream in signal transduction from cell surface to nucleus) | Sex diff | Ovary/females |
| Wnt-5a (ligand for members of the frizzled receptors, activates or inhibits canonical Wnt-signaling, depending on receptor context) | Sex diff | Ovary/females |
aFunctions taken from http://www.uniprot.org