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. Author manuscript; available in PMC: 2014 Oct 20.
Published in final edited form as: JAMA Neurol. 2013 May;70(5):571–579. doi: 10.1001/jamaneurol.2013.172

Table 5. Comparison of Parkin and Parkinson Disease Cases.

Mean (Range)
Parkin Parkinson Disease P Value Test
Cases 5 5
Sex
 Male 2 5
 Female 3 0
Age at onset, y 33.6 (25-46) 45.2 (36-64) .09 t test
Disease duration, y 38.3 (27-50) 26.1 (21-31) .03a MWU
Age at death, y 71.9 (60-86) 71.3 (61-81) .84 MWU
VNN density, neurons/mm2 8 (3-13) 7.7 (6-11) .89 t test
DNN density, neurons/mm2 19.2 (15-22) 14.3 (10-20) .04a t test
Total nigra neuronal density, neurons/mm2 14.3 (12-18) 11.7 (9-14) .12 t test
Ratio of VNN/DNN 0.41 (0.12-0.60) 0.55 (0.39-0.77) .26 t test

Abbreviations: DNN, dorsal nigral neuronal; MWU, Mann-Whitney U test; VNN, ventral nigral neuronal.

a

Significant at the P < .05 level.