Figure 1.

Pain scores of formalin-induced nociceptive behaviors (mean ±S.E.M. of 8–10 mice per group) following injection of saline (10 ml/kg) or hydroalcoholic extract of Tanacetum sonbolii (A1-A6) measured every 3 min for a total 60-min period and bar chart for different doses of Tanacetum sonbolii 75, 150, 300, 600, 900, and 1200 mg/kg in the formalin test and control group (B1-B6). Columns represent the mean nociceptive score in each phase: phase 1 (minutes 1–7), inter phase (minutes 8–14), and phase 2 (minutes 15–60) (B1-B6). The mice received Tanacetum sonbolii Mozaff 30 min before formalin injection in the right hind paw. Recording of the nociceptive behaviors began immediately after formalin injection (time 0) and continued for 60 min. For clarity, each dose of Tanacetum sonbolii was plotted in separate graphs, with the same vehicle group in each.

*P < 0.05; ** P < 0.01 and ***P < 0.001 compared with saline