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Effect of gemcitabine and 5-FU on LDR-induced cell cycle changes. HCC cell lines were treated with 30 nM gemcitabine or 3 μM 5-FU 24 hours before LDR (0.26 Gy/h for 16 hours). Cells were stained with PI and analyzed by flow cytometry. Shown are representative histograms at 24 hours after LDR (A), cell cycle distribution after LDR (B), and the percentage of Hep3B cells in G2/M at the indicated time points after LDR (C).
