Table 1.
Radiosensitization in Hepatocellular Carcinoma
| Dose rate Total dose |
Gem 30 nM |
Gem 100 nM |
5-FU 1 μM |
5-FU 3 μM |
Sorafenib 3 μM |
Sorafenib 10 μM |
|---|---|---|---|---|---|---|
| A. Enhancement Ratios for Hep3B Cells with Low and Standard Dose Rate Radiation | ||||||
| LDR 0.07 Gy/h 1.1 Gy |
0.99 | 1.14 | 2.26 | 1.81 | 1.61 | 1.19 |
| LDR 0.10 Gy/h 1.6 Gy |
1.62 | 1.55 | 1.02 | 3.51 | 1.22 | 2.36 |
| LDR 0.26 Gy/h 4.2 Gy |
1.90 | 2.31 | 7.92 | 13.85 | 1.58 | 5.55 |
| SDR 2 Gy/min 2 Gy |
1.27 | 1.73 | 1.48 | 1.18 | 1.14 | 1.58 |
| SDR 2 Gy/min 4 Gy |
1.03 | 1.41 | 1.87 | 2.84 | 1.56 | 2.09 |
| B. Enhancement Ratios for HepG2 Cells with Low and Standard Dose Rate Radiation | ||||||
| LDR 0.07 Gy/h 1.1 Gy |
2.06 | 2.69 | 1.89 | 2.09 | 0.91 | 4.19 |
| LDR 0.10 Gy/h 1.6 Gy |
2.42 | 2.83 | 2.03 | 1.95 | 1.24 | 4.50 |
| LDR 0.26 Gy/h 4.2 Gy |
2.16 | 2.87 | 2.16 | 3.30 | 1.05 | 2.61 |
| SDR 2 Gy/min 2 Gy |
1.63 | 0.94 | 0.92 | 1.72 | 1.10 | 1.48 |
| SDR 2 Gy/min 4 Gy |
1.53 | 1.19 | 2.45 | 1.79 | 1.46 | 1.11 |