Table 2.
Patients Treated with 90Y Microspheres and Gemcitabine
| Radiation Dose Gy¶ | Gemcitabine Dose mg/m2 | Diagnosis | Number of Lesions | Vascular Involvement | Overall Survival Months | Time to Local Failure | Best Response (RECIST) | |
|---|---|---|---|---|---|---|---|---|
| 1 | 99.3 | 200 | Hepatocellular | 8 | No | 6.9 | 6.9‡ | CR |
| 2A§ | 80.2 | 200 | Hepatocellular | 4 | No | 32.9⁎ | 16.8 | PR |
| 2B§ | 155.0 | 200 | Hepatocellular | 4 | No | 17.9 | PR | |
| 3 | 85.3 | 200 | Hepatocellular | 2 | Yes | 12.3 | 9.9 | PR |
| 4 | 115.7 | 400 | Hepatocellular | 1 | No | 21.1⁎ | 3.8 | PD |
| 5 | 130.0 | 200 | Hepatocellular | 5 | No | 12.5 | 7.1 | SD |
| 6A§ | 97.4 | 200 | Melanoma | 8 | No | 27.7 | 6.4 | PR |
| 6B§ | 134.5 | 200 | Melanoma | > 10 | No | 7.8 | PR | |
| 7 | 102.4 | 200 | Melanoma | > 10 | No | 5.0 | 1.6 | PR |
| 8 | 89.0 | 200 | Melanoma | > 10 | No | 6.6† | 3.4 | PD |
| 9A§ | 103.7 | 200 | Melanoma | > 10 | No | 9.2 | 6.8 | SD |
| 9B§ | 109.8 | 200 | Melanoma | > 10 | No | 4.9 | PD | |
| 10 | 85.7 | 200 | Melanoma | > 10 | No | 15.9 | 9.3 | SD |
| 11 | 124.4 | 200 | Cholangio | > 10 | No | 2.2 | 2.2‡ | PD |
| 12 | 110.2 | 400 | Cholangio | > 10 | Yes | 5.5 | 6.4 | PD |
| 13 | 92.7 | 200 | Carcinoid | > 10 | No | 10.4 | 10.4‡ | SD |
⁎
Alive at time of analysis.
†
Lost to follow up.
‡
No local progression at time of death.
§
Treated to separate regions at different times.
¶
Calculated dose to lobe.